Sucrose Feeding in Man Effects on Substrate Incorporation into Hepatic Triglycerides and Phosphoglycerides in Vitro and on Removal of Intravenous Fat in Patients with Hyperlipoproteinemia

Abstract

Thirty-five patients operated on for uncomplicated gallstone disease were studied. Eight patients with prebeta hyperlipoproteinemia and 11 normolipo-proteinemic patients had sucrose substituted for 800 Kcal of their daily caloric intake for two weeks prior to the operation. Sixteen patients served as non-sucrose-fed controls. In the normolipoproteinemic patients sucrose feeding produced an elevation of plasma triglycerides, a transient decrease in cholesterol, increase in basal insulin concomitant with an increased adipose tissue lipoprotein lipase activity. Only basal insulin increased significantly in prebeta hyperlipoproteinemia. Liver triglyceride and glycogen contents were elevated after sucrose feeding, while phosphoglyceride content was lower in prebeta hyperlipoproteinemia than in normolipoproteinemia. After sucrose feeding a higher and in normolipoproteinemia and prebeta hyperlipoproteinemia similar incorporation rate of labeled precursors into hepatic triglycerides was observed. The incorporation rate into choline phosphoglycerides was lower in prebeta hyperlipoproteinemia than in patients with initially normal serum lipid values. Sucrose feeding in normolipoproteinemic gallstone patients enhances triglyceride synthesis in the liver and also the adipose tissue lipoprotein lipase activity. In prebeta hyperlipoproteinemia, sucrose feeding causes a reduced capacity for hepatic phosphoglyceride synthesis.

Key Words:

• Lipoprotein lipase
• phospholipid synthesis
• human liver
• plasma lipids
• human
• prebeta hyperlipoproteinemia
• sucrose feeding
• lipid metabolism
• triglyceride synthesis
• human liver