The Oxygen Dissociation Curve of Normal Human Blood with Special Reference to the Influence of Physiological Effector Ligands

G. Arturson Dept. of Clinical Physiology and Burn Center, University Hospital, Uppsala, Sweden; Dept. of Physiology, University of Odense, Denmark

L. Garby Dept. of Clinical Physiology and Burn Center, University Hospital, Uppsala, Sweden; Dept. of Physiology, University of Odense, Denmark

M. Robert Dept. of Clinical Physiology and Burn Center, University Hospital, Uppsala, Sweden; Dept. of Physiology, University of Odense, Denmark

B. Zaar Dept. of Clinical Physiology and Burn Center, University Hospital, Uppsala, Sweden; Dept. of Physiology, University of Odense, Denmark

Abstract

The effect of changes in effector ligand activity on the oxygen affinity of human whole blood was calculated for protons, carbon dioxide, and 2,3-diphosphoglycerate (DPG) at various concentrations of these ligands. The data were used to obtain, from experimentally obtained oxygen dissociation curves of blood from apparently healthy subjects, the standard oxygen dissociation curve (pH = 7.40, Pco₂ = 40 mm Hg, DPG = 5.0 mmol/l, and HbCO = 1.0%) of normal human blood.

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The Oxygen Dissociation Curve of Normal Human Blood with Special Reference to the Influence of Physiological Effector Ligands

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The Oxygen Dissociation Curve of Normal Human Blood with Special Reference to the Influence of Physiological Effector Ligands

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