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Abstract
A radioimmunological method for determination of the pregnancy specific β1-glycoprotein (SP1) is described. Antigen specificity of rabbit anti-human SP1 serum (Behringwerke) was investigated against human placental and pituitary hormones. The sensitivity was about 10 μg/l. The concentration ranges of SP1 in umbilical cord blood and amniotic fluid were 0·10–0·60 mg/l and 0·3–3·8 mg/l, respectively. A good correlation (r = +0·95) was found between the radioimmunological and electroimmunological methods for determination of SP1 in maternal blood.