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Original Article

Effect of Verapamil on pancreatic glucagon release from the isolated, perfused canine pancreas

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Pages 139-142 | Received 22 Sep 1976, Accepted 09 Dec 1976, Published online: 08 Jul 2009
 

Abstract

The effect of Verapamil, a potent calcium antagonist, upon pancreatic glucagon release was investigated in the isolated, perfused canine pancreas. Verapamil at concentrations ranging between 10−5-10−4 mol/I caused a dosc-related inhibition of glucagon release at a glucose concentration of 25 mg/dl. The inhibition was an immediate and reversible phenomenon. The inhibitory effect was reduced when the Ca2+ concentration was increased from 1.3 to 5.0 mmol/I. The results are compatible with earlier findings from our laboratory demonstrating that calcium plays a key role in the stimulus-secretion coupling of glucagon release.

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