9
Views
6
CrossRef citations to date
0
Altmetric
Original Article

The Diuretic effect of secretin in man

, , &
Pages 381-387 | Received 29 May 1979, Accepted 20 Aug 1979, Published online: 08 Jul 2009
 

Abstract

Six young healthy male students were studied with an intravenous infusion of 50 ml/h saline for three 2 h periods. In the second 2 h period pure natural secretin was added to the saline infusion in a dose of 2 CU/kg h. Urine was collected separately in the three 2 h periods, and blood was drawn every 1 h. Urinary water, sodium, potassium, chloride, calcium, creatinine and solute excretion increased significantly during the 2-h secretin period. The clearance of sodium, potassium, chloride, calcium and solutes as a percentage of glomerular filtration rate (creatinine clearance) increased significantly, whereas tubular reabsorption of sodium as a percentage of filtrated sodium decreased significantly during secretin infusion. Even though plasma secretin remained elevated in the first half of the last 2 h control period, no diuretic effect was noted in this period. It would appear therefore that the diuretic effect of secretin most likely is a pharma-gological effect only.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.