Changes of urinary kallikrein and kinin excretions induced by adrenalin infusion in conscious dogs

Abstract

A subpressor dose of adrenalin (0.5 mg/h) infused intravenously into nine conscious trained dogs increased urine kinin excretion from 41 ±9 ng/h to 191 ± 29 ng/h. The effect was abolished by phenoxybenzamin pretreatment (1 mg/kg). In a-blocked condition adrenalin increased urine TAMe-esterase activity from 12.7 ± 2.3 mEU/h to 15.7 ± 2.8 mEU/h whilst in β-blocked condition the catecholamine decreased urine enzyme activity from 12.7 ± 1.0 mEU/h to 11.7 ± 1.1 mEU/h. Adrenalin invariably decreased urine sodium excretion. In comparable experiments with dopamin (1.0 mg/h) a slight natriuresis was observed, yet urine kallikrein and urine kinin excretions remained unmodified.

Key Words:

• catecholamines
• kallikrein
• kidney
• kinin
• sodium excretion