Exercise-induced proteinuria in children and adolescents

Abstract

Urinary albumin and β₂,-microglobulin excretion rates were measured by radioimmunological methods in 60 children and adolescents at rest and during physical exercise. The geometric mean of the albumin excretion rate was 4.4 (μg/min)/m² at rest and rose to 7.9 (μg/min)/m² during exercise (P<0.001), while the geometric mean of β₂-microglobulin was 31.9 (ng/min)/m² at rest and 26.2 (ng/min)/m² during exercise. These results indicate that exercise-induced proteinuria is of a glomerular leaking type. The albumin excretion rate was not dependent on the age or sex of the subjects. The exercise-induced albuminuria correlated weakly but significantly with the maximal blood pressure (r = 0.27; P<0.05) and with the physical fitness of the subjects (r = 0.28; P<0.05).

Key Words:

• adolescents
• albumin
• β₂-microglobulin
• children
• exercise
• proteinuria