Concentrations of baclofen in serum and breast milk from a lactating woman

Abstract

A lactating woman with spastic paraplegia was given 94 μmol (20 mg) of baclofen orally to study the transport of the drug into breast milk. The concentration of baclofen in serum and milk was determined with a gas chromatographc-mass pectrometric method. The elimination curves in serum and milk showed a similar course, the elimination from milk being delayed about 3 h relative to serum. The total amount of baclofen excreted in the milk during 24 h was about one thousandth of the ingested dose.

Key Words:

• baclofen
• breast milk
• gas chromatography-mass spectrometry
• pharmacokinetics