Red cell filterability and chronic renal failure

Abstract

Filterability has been studied during chronic renal failure (with creatinin level above 350 μmol/l); red cells were washed thrice with 9 g/l NaCl or 40 g/l human serum albumin), adjusted to give a PCV of 0.3 and filtered on polycarbonate sieves with pore sizes of 5 μm.

In the uremic patients group, the results are heterogeneous and show a significant reduction of the red cell filterability. The filtration time is not well correlated with the degree of uraemia but with the haemoglobin level.

Key Words:

• Uraemia
• anaemia