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Abstract
We present reference values for the excretion of cAMP in spot urine collected between 09.00 and 12. 00 hours in 143 healthy children aged 2-200 months. The excretion of cAMP was creatinine-corrected and expressed as a substance concentration ratio (UcAMP/crea),U due to a positive significant correlation between the excretion of cAMP and creatinine (r=0.68, p<0.001). The mean value (95% significance limits) for (UcAMP/crea)U was 748 μmol/mol (254-2206 μmol/mol). A logarithmic transformation of the ratio was used, since preliminary analysis showed uneven distribution; when the logarithmic transformation was used, the data appeared evenly distributed. There was no significant difference between the results for girls and boys. The value of lg(UcAMP/crea)U was related to the age or body surface area with decreasing values at higher age or body surface area. (r=-0.55 and r=-0.57, p<0.001). Spot urine for measurement of urinary cAMP instead of a 24 h collection appears preferable due to the practicability of the test in children.