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Scandinavian Journal of Clinical and Laboratory Investigation Volume 46, 1986 - Issue 2
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Original Article

Relative affinities of estramustine phosphate metabolites to the cytosol oestrogen receptor of rat testis

Lars Dahlin Department of Urology and Andrology, University of Umeå, Sweden; Department of Physiology, University of Umeå, Sweden
,
Ragnar Södergård Department of Obstetrics and Gynecology, University of Umeå, Sweden
&
Jan-Erik Damber Department of Urology and Andrology, University of Umeå, Sweden; Department of Physiology, University of Umeå, Sweden
Pages 159-162 | Received 24 May 1985, Accepted 23 Oct 1985, Published online: 08 Jul 2009
 
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Abstract

A competitive binding assay was used for analysis of the affinities of ethinyl oestradiol, diethylstilboestrol and metabolites of estramustine phosphate to the oestrogen receptor of rat testis. The affinities were ranked as follows: ethinyl oestradiol > oestradiol-17β > diethylstilboestrol » estramustine. Estramustine did not reveal any oestrogen receptor affinity. The results support the concept that estramustine and estromustine do not mediate the oestrogenic effects of estramustine phosphate. The oestrogenicity of estramustine phosphate is suggested to be mainly due to the metabolite oestradiol-17β

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