Abstract
Certain aspects of somatostatin secretion from isolated rat pancreatic islets are described. A considerable, but falling basal secretion of somatostatin was observed in the pre-incubation periods. Both glucose and theophylline stimulation gave significant increases in somatostatin secretion, whereas carbachol inhibits the somatostatin secretion at 25 mmol T1 glucose but not at 5 mmol 1_1 glucose. The glucose effect on somatostatin secretion required a normoglycaemic pre-incubation level of 5.5 mmol 1_1 glucose. Our results indicate that somatostatin secretion from isolated pancreatic islets is strongly dependent on the experimental conditions.
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