Plasma and renal clearance of iohexol–a study on the reproducibility of a method for the glomerular filtration rate

Abstract

The reproducibility of iohexol clearance as a determination of the glomerular filtration rate was assessed in 12 healthy subjects during triplicate constant-rate infusions. Renal and plasma clearance of iohexol demonstrated a total within-subject variation (CV) ranging between 0% and 16%. The inter-individual variation in renal clearance was about 10%, the clearance values being (mean±SD) 116±10, 117±9 and 110±12 ml/min 1.73 m² in the three experiments and corresponding figures for the plasma clearance were 120+17,118112 and 112±14 ml/min 1.73 m². The renal clearance (CL_R) and the plasma clearance (CL) showed good correlation (regression equation CL = 11.80+0.93 CL_R, r_s = 0.67).

The method is simple and reproducible; thus, it is suitable for both clinical examinations and research.

Key Words:

• GFR
• healthy volunteers
• iohexol