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Original Article

The clearance of iohexol as a measure of the glomerular filtration rate in children with chronic renal failure

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Pages 729-734 | Received 14 Jun 1991, Accepted 26 Sep 1991, Published online: 08 Jul 2009
 

Abstract

The plasma clearances of technetium-99m-labelled DTP A ([99Tcm]-DTPA) and the non-ionic contrast medium iohexol were estimated in 11 children with chronic renal failure for determination of the glomerular filtration rate (GFR). Equal values were obtained with the two substances provided plasma sampling was simultaneous, but when plasma was sampled within 3.5 h after injection of iohexol and [99Tcm]-DTPA the GFR was overestimated by more than 50%. For clearance values below 20 ml min-1 1.73 m-2, valid GFR estimates were obtained both from two plasma samples taken 3 h and 24 h after the injection of iohexol and from a single plasma sample taken 24 h after the injection.

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