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Scandinavian Journal of Clinical and Laboratory Investigation Volume 53, 1993 - Issue 1
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Original Article

Effect of allopurinol on myocardial recovery during reperfusion

H. Soncul Department of Thoracic and Cardiovascular, Surgery of Gazi University Medical School, Ankara, Turkey
,
L. Gökgoz Department of Thoracic and Cardiovascular, Surgery of Gazi University Medical School, Ankara, Turkey
,
S. Kalaycioglu Department of Thoracic and Cardiovascular, Surgery of Gazi University Medical School, Ankara, Turkey
,
V. Sinci Department of Thoracic and Cardiovascular, Surgery of Gazi University Medical School, Ankara, Turkey
,
M. Kaptanoglu Department of Thoracic and Cardiovascular, Surgery of Gazi University Medical School, Ankara, Turkey
&
A. Ersöz Department of Thoracic and Cardiovascular, Surgery of Gazi University Medical School, Ankara, Turkey
Pages 11-15 | Received 23 Dec 1991, Accepted 26 Jun 1992, Published online: 08 Jul 2009
 
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Abstract

Soncul H, Gökgöz L, Kalaycioglu S, Sinci V, Kaptanoglu M, Ersöz A. Effect of allopurinol on myocardial recovery during reperfusion. Scand J Clin Lab Invest 1993; 53: 11-15.

A comparative study on isolated guinea pig hearts was carried out to determine the effect of allopurinol added to reperfusion solution on myocardial recovery after global ischaemia. After 20 min of normothermic ischaemia two groups of solutions (1-Krebs Solution 2-K.rebs Solution + Allopurinol 1 mmol l−1) were used for reperfusion (10 animals in each group). Post-ischaemic myocardial functions (ventricular contractile force and heart work) and enzyme activities (CK-MB, LD) were compared with their preischemic values.

Addition of allopurinol 1 mmol l−1 to reperfusion solution improved post-ischaemic myocardial functions and decreased myocardial injury.

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