Thyroid antibodies in association with thyroid malignancy II: qualitative properties of thyroglobulin antibodies

A.-M. Haapala Division of Clinical Immunology, Department of Clinical Microbiology, Tampere University Hospital, Tampere, Finland

E. Soppi Division of Clinical Immunology, Department of Clinical Microbiology, Tampere University Hospital, Tampere, Finland

P. Mörsky Department of Clinical Chemistry, Tampere University Hospital, Tampere, Finland

J. Salmi Department of Medicine, Tampere University Hospital, Tampere, Finland

S. Laine Division of Clinical Immunology, Department of Clinical Microbiology, Tampere University Hospital, Tampere, Finland

J. Mattila Department of Pathology, Tampere University Hospital, Tampere, Finland

Abstract

Qualitative properties of thyroglobulin (Tg) antibodies, in association with thyroid malignancy, suspected malignancy or other thyroid diseases, were studied in 177 patients. Retrospective clinical analysis revealed 137 patients to have thyroid carcinoma and 40 to have other thyroid diseases. Serum Tg was assayed by an immunoradiometric method. Thyroid microsomal (AMC) and Tg antibodies were measured by the particle agglutination method and the avidity of Tg antibodies by enzyme immunoassay (EIA). Assessment of the qualitative properties of Tg antibodies revealed that the high-avidity antibodies especially seem to bind circulating Tg. Thus any Tg value from a sample with detectable Tg antibodies is unreliable and should be interpreted with caution.

Key Words:

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Thyroid antibodies in association with thyroid malignancy II: qualitative properties of thyroglobulin antibodies

Information for

Open access

Opportunities

Help and information

Thyroid antibodies in association with thyroid malignancy II: qualitative properties of thyroglobulin antibodies

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature