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Original Article

Chronic hepatitis C: T-helperl/T-helper2 imbalance could cause virus persistence in peripheral blood

, , , , , , , & show all
Pages 703-710 | Received 02 May 1997, Accepted 10 Sep 1997, Published online: 08 Jul 2009
 

Abstract

Interferon gamma (IFNγ) and interleukin 4, 10 and 12 (IL-4, -10, -12) production was measured in whole peripheral blood (WPB) and peripheral blood mononuclear cells (PBMC) of 10 chronic hepatitis C (CHC) patients. The level of IFNγ in supernatants in mitogen-activated WPB was lower than in healthy donors. IL-10 served as a possible downregulative factor for IFNγ, since its spontaneous IL-10 production was enhanced in CHC. Neutralization of IL-10 partly restored IFNγ response in CHC patients. Recombinant IL-12 (rIL-12) also enhanced IFNγ of CHC patients, but IL-12 production was decreased in CHC. Thus, IFNγ production deficiency in CHC patients is secondary to blockage by high levels of IL-10-impaired IL-12 production.

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