Non-invasive evaluation of the fibrosis stage in chronic hepatitis C: A comparative analysis of nine scoring methods

Abstract

Objective. Liver biopsy is an invasive procedure and new surrogate markers to assess fibrosis are needed. We performed a comparative external evaluation of nine non-invasive scores of liver fibrosis and tried to identify other potential biochemical markers of low-stage liver fibrosis in chronic hepatitis C (CHC). Material and methods. We included 429 previously untreated consecutive patients from a single centre who underwent a liver biopsy between January 1999 and April 2009. Biopsies were evaluated for the stage of fibrosis according to the METAVIR scoring method. Results. None of the evaluated scores were adequate to disclose null–low fibrosis due to a lack of specificity at the proposed cut-offs and the poor sensitivity of lower cut-offs. Serum ferritin and cholesterol values were found to be independently related to the fibrosis stage and their inclusion in the best performing scores at lower cut-off values (the APRI and King’s scores) improved the sensitivity for null–low fibrosis by 8% with a specificity ≥ 93%. Conclusions. Approximately 30% of patients with null–low fibrosis may be accurately identified by supplementing current scores with new independent variables (serum ferritin and cholesterol), thus obviating the need for a liver biopsy.

Key Words::

• Chronic hepatitis C
• liver biopsy
• liver fibrosis
• non-invasive tests
• serum cholesterol
• serum ferritin

Acknowledgements

This work was supported in part by a research grant from Schering-Plough. The authors report no conflicts of interest.