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Review

Fecal calprotectin in diagnosis and clinical assessment of inflammatory bowel disease

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Pages 74-80 | Received 04 Nov 2014, Accepted 11 Nov 2014, Published online: 19 Dec 2014
 

Abstract

The fecal neutrophil-derived biomarker calprotectin has several features of an ideal noninvasive test for detecting intestinal inflammation: it is simple, reliable, and low in cost. Its utility in differentiating inflammatory bowel diseases (IBDs) from functional conditions such as irritable bowel syndrome is well documented. Fecal calprotectin (FC) correlates closely with endoscopic activity of IBD. Emerging evidence suggest its usefulness in serial monitoring of disease activity and of therapy success in IBD. A low FC concentration predicts persistence of clinical remission especially in non-symptomatic ulcerative colitis and Crohn’s colitis. Here, an overview is given to the current role of FC in diagnosis and clinical assessment of IBD.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

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