Total Protein and Total Nitrogen in Gastrin-Stimulated Gastric Secretion of Man

Abstract

Total protein (Prot) and total nitrogen (TN) contents of gastric juice were determined in 20-minute portions withdrawn by continuous suction for one hour before and one hour after subcutaneous injection of Gastrin Leo (2 μg/kg body weight) in 19 patients. In 9 of these patients the examination was performed twice. There was an increased concentration ([ ]) and output (Q) of Prot and a decreased [TN] following gastrin administration. The QTN, however, was shown to increase significantly in the post-gastrin hour. It was found that a statistically significant correlation existed between hydrochloric acid concentration ([TA]) and [TN] after gastrin, and between QTA, QProt and QTN before as well as after injection of gastrin. Comparison with values of Prot and TN in gastric juice found by others indicated that gastrin affects the gastric secretion of these substances in the same way as histamine.

Index-words:

• Stomach
• gastric juice
• gastric acidity determination
• nitrogen
• proteins

Notes

This study was aided in part by grants from Oslo kommunes medisinsk-vitenskapelige forskningsfond, The Norwegian Research Council for Science and the Humanities (Grant No. 103.50). and Nordisk Insulinfond.