The Effect of 1-Hyoscyamine on Gastric Secretion of Acid and Pepsin in Man

Abstract

After collecting basal secretion for 30 minutes a histamine infusion was started. The infusion speed was increased every 15 minutes. The histamine infusion lasted 1 1/2 hours. During histamine stimulation there was a continuous increase in volume, acid concentration, acid output, and pepsin output for every period. Treatment with 1-hyoscyamine, which prior to the second investigation had been given for at least 2 1/2 weeks, resulted in a lowered volume, acid concentration, and acid output, during all periods of histamine stimulation. The pepsin concentration was also slightly lower for every period during treatment, resulting in a marked decrease in pepsin output.

Key-words:

• Atropine
• duodenal ulcer
• gastric juice
• histamine
• 1-hyoscyamine
• pepsin