Variability of the Sum of Bicarbonate and Chloride Concentrations in the Pancreatic Juice of the Dog

Abstract

A study of the electrolyte content of pancreatic juice in 20 anaesthetized dogs showed that the sum of bicarbonate and chloride and the sum of bi-cabonate, chloride, sodium and potassium concentrations were variable in the course of a single experiment in most animals. The only factor of variation was bicarbonate concentration. These facts are compatible with the ‘admixture theory’. On the condition that some postulations are made, it becomes possible to calculate the composition of the components of the juice, on the basis of a two-component hypothesis. Comparison between our results and those of others in the gastric juice suggests that the neutral components of gastric and pancreatic juices are secreted through similar processes.

Key-words:

• Pancreas
• pancreatic juice
• pancreozymin
• secretin