The Response of Human Gastric Tissue Eosinophils to ACTH Infusion and to Long-Term Treatment with Prednisone

M. Siurala Gastroenterological Department, Second Department of Medicine, University Central Hospital, Helsinki, Finland

T. Räsänen Gastroenterological Department, Second Department of Medicine, University Central Hospital, Helsinki, Finland

K. Varis Gastroenterological Department, Second Department of Medicine, University Central Hospital, Helsinki, Finland

Abstract

After 60 units of ACTH, a marked increase in tissue eosinophilia occurred at 3 hours in 3 out of 5 cases, followed at 6 hours by a significant decrease in all cases. After 120 units of ACTH, mucosal eosinophils showed a significant decrease in all cases 8 hours after the start of the treatment. In both experiments blood eosinophils showed a continuous and strong decrease in all cases. Long-term treatment with 20 mg/day of prednisone caused a significant decrease of gastric mucosal eosinophilia at 2 weeks, followed by an additional decrease 12 weeks after the start of the treatment.

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The Response of Human Gastric Tissue Eosinophils to ACTH Infusion and to Long-Term Treatment with Prednisone

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The Response of Human Gastric Tissue Eosinophils to ACTH Infusion and to Long-Term Treatment with Prednisone

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