Succinic Dehydrogenase Activity in the Gastric Mucosa of Rats during Hyperthermia

L. S. Semb Institute for Experimental Medical Research, Laboratory of Gastroenterology, Department IX, and Department of Pathological Anatomy, University of Oslo, Ullevål Hospital, Oslo, Norway

J. Myren Institute for Experimental Medical Research, Laboratory of Gastroenterology, Department IX, and Department of Pathological Anatomy, University of Oslo, Ullevål Hospital, Oslo, Norway

O. B. Reite Institute for Experimental Medical Research, Laboratory of Gastroenterology, Department IX, and Department of Pathological Anatomy, University of Oslo, Ullevål Hospital, Oslo, Norway

Abstract

The activity of succinic dehydrogenase (SDH) was examined in the gastric mucosa of 11 rats with normal body temperature (controls) and 11 rats with a body temperature maintained at 41-42° C for one hour in a thermostat. The pH of the mucosal surface of the glandular stomach was determined. The hyperthermic rats had an enlarged and congested gastrointestinal tract with a pH above 5 in the gastric content, whereas the stomachs of the controls were small and contracted with pH 1-2. No reduction was found in SDH activity of parietal cells that could account for the reduced hydrochloric acid secretion in hyperthermic animals.

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Succinic Dehydrogenase Activity in the Gastric Mucosa of Rats during Hyperthermia

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Succinic Dehydrogenase Activity in the Gastric Mucosa of Rats during Hyperthermia

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