Acid Base Changes Due to Secretin Administration in Normal Patients and in Patients with Pancreatic Disease

Abstract

The fall in blood base occurring after the administration of secretin and the aspiration of duodenal contents was assessed in normal patients and in patients with chronic pancreatitis. In contrast to normal patients, those with chronic pancreatitis showed only a small fall or no fall in blood base level. There was no correlation between the amount of bicarbonate as determined by aspiration and that calculated from the blood base change. In 3 normal patients the magnitude of the renal compensatory mechanism in the post-secretin hour was found to be insignificant.

Key-words:

• Acid-base equilibrium
• pancreas
• pancreatic juice
• pancreatitis