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Original Article

Application of Whole Body Counting to the Measurement of Vitamin B12 Absorption with Reference to Achlorhydria

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Pages 397-405 | Received 28 Oct 1968, Accepted 10 Jan 1969, Published online: 25 Feb 2010
 

Abstract

Three hundred vitamin B12 (B12) absorption tests were carried out by whole body counting: sequential scanning may detect errors due to un-absorbed and unexcreted radioactivity. There was a poor correlation between two successive absorption tests in the same patient in the fasting state. The correlation improved when B12-free meals were used, particularly in controls and achlorhydric patients without pernicious anaemia (PA). Single tests in the fasting state could not always distinguish between patients with and with-without PA. No constant relationship between intrinsic factor (IF) production following histamine or pentagastrin stimulation and B12 absorption could be found in achlorhydric patients without small intestinal disease.

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