The Duodenal Aspirate Following Secretin Stimulation a Variance Study in Man

Abstract

The intra- and interindividual variances of variables in duodenal aspirates following a standard dose of highly purified secretin were calculated from 21 examinations in 15 healthy young males and 50 examinations in 22 patients with and without pancreatic disease. The mean interval between repeated examinations was 3 weeks in healthy males and 28 weeks in patients. Comparison of the variances showed that the bicarbonate output provided more reliable information on the individual response to secretin than the volume and bicarbonate concentration both in healthy males and patients. The 20-minute peak values were not superior to the corresponding values of the total one-hour aspiration period in differentiating between individuals.

Key-words:

• Pancreas
• pancreatic juice
• secretion
• statistics