The Effect of Estriol Succinate upon Healing of Duodenal Ulcer: a Controlled Study

Abstract

The effect of estriol-16, 17-dihemisuccinate, an estrogen without significant feminizing side-effects, on the healing of duodenal ulcer was studied, using a double-blind method. Of 43 patients 18 received 10 mg of the drug daily and 25 received placebo tablets during 2 months. There was no statistical difference in the disappearance of subjective complaints. However, roentgenologically improvement of the ulcer was noted in 13 out of 16 treated and in 12 out of 25 controls, the difference being statistically significant (P = 0.01-0.02).

Key-words:

• Duodenal ulcer
• estriol
• stomach