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Abstract
The stimulating effect on the gastric secretion of pepsin of an intravenous injection of one clinical unit of pure secretion per kg body weight was compared to the effect of a subcutaneous injection of 50 μg histamine dihydrochloride per kg body weight in the same series of subjects. The pattern of the pepsin response differed markedly. The ratio between the amounts of pepsin and HCl secreted decreased after injection of histamine, whereas it increased after injection of secretin. The effect of secretin on the pepsin/HCl ratio lasted for about two hours.