Inhibition of Pentagastrin-induced Gastric Acid Secretion in Man by Glucagon Given Intravenously

Abstract

The effect of 2 mg of glucagon given intravenously on the pentagastrininduced gastric acid secretion was studied in 8 patients with peptic ulcer disease. On the maximal acid output produced by pentagastrin glucagon induced a moderate but significant depression of the secretion. When a submaximal pentagastrin infusion of 0.0025 μg/kg/min was given, glucagon induced approximately a 50 % decrease of the gastric acid output. Glucagon inhibits the basal as well as the pentagastrin-stimulated gastric acid secretion, but not the secretion in response to a maximal dose of histamine.

Key-words:

• Gastric acidity determination
• gastric juice
• gastrin
• glucagon
• stomach