Effect of Nicotinic Acid on Gastric Secretion of Acid in Human Subjects and in Dogs

S. Andersson Dept. of Internal Medicine, Gastroenterological Laboratory, Karolinska Sjukhuset, Dept. of Pharmacology, Karolinska Institutet, Stockholm, and Dept. of Geriatrics, Uppsala University, Uppsala, Sweden

L. A. Carlson Dept. of Internal Medicine, Gastroenterological Laboratory, Karolinska Sjukhuset, Dept. of Pharmacology, Karolinska Institutet, Stockholm, and Dept. of Geriatrics, Uppsala University, Uppsala, Sweden

L. Orö Dept. of Internal Medicine, Gastroenterological Laboratory, Karolinska Sjukhuset, Dept. of Pharmacology, Karolinska Institutet, Stockholm, and Dept. of Geriatrics, Uppsala University, Uppsala, Sweden

E. A. Richards Dept. of Internal Medicine, Gastroenterological Laboratory, Karolinska Sjukhuset, Dept. of Pharmacology, Karolinska Institutet, Stockholm, and Dept. of Geriatrics, Uppsala University, Uppsala, Sweden

Abstract

The effect of nicotinic acid on gastric secretion was studied in 19 fasting patients who had coronary heart disease and hyperlipoproteinemia. Among 10 patients with basal secretion of acid, 9 had increased acid output following oral administration of 0.5 g of nicotinic acid — the increase ranged from 13 to 232 per cent. Also in Pavlov pouch dogs, i.v. infusion of nicotinic acid gave rise to a significant increase in gastric acid output. The mechanism behind gastric stimulatory action of nicotinic acid is unknown.

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Effect of Nicotinic Acid on Gastric Secretion of Acid in Human Subjects and in Dogs

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