Effect of a Duodenal Tube on the Gastric Secretion of cid and Pepsin in Man

Abstract

The ‘basal’ gastric secretion collected during 3 hours with a gastric Levin tube and a gastroduodenal Lagerlöf tube was compared in 11 subjects. The Lagerlöf tube gave significantly higher pepsin output, pepsin concentration, and pepsin/acid ratio than the Levin tube, and showed a significant non-steady state level of volume, acid concentration, acid output, pepsin output, and pepsin/acid ratio. The effect of the Lagerlöf tube was not dependent on the duodenal drainage. Perfusing the duodenum with secretin-stimulated duodenal juice in 4 subjects did not stimulate more pepsin than the tube alone.

Key-words:

• Gastric secretion
• hydrochloric acid determination
• pepsin