The Effect of Phthalapromine (LU 3–010) on Gastric Motility in Man

Abstract

Recording of the intragastric pressure/volume relationship has been undertaken in patients with duodenal ulcer before and after administration of 30 mg LU 3–010 (phthalapromine) i. v. The gastric pressure was recorded by means of a large, thin-walled plastic bag, a technique previously described. The results showed a depressing effect of LU 3–010 on gastric motility. Peristaltic peaks slowly reappeared in the course of an hour, but increasing gastric volume had a trigger-effect on the motility. The possible ways of action are discussed. As the drug seems effective in abolishing gastric hypermotility it may prove useful in the treatment of duodenal ulcer.

Key-words:

• Gastric motility
• duodenal ulcer
• phthalapromine