Antral and Duodenal Gastrin Activity in Non-Ulcer and Ulcer Patients

Abstract

The secretory activity of gastrin extracts from the antral and duodenal mucosa of patients operated on for duodenal or gastric ulcer, and from non-ulcer patients, was determined on conscious cats. The antral gastrin activity in the duodenal ulcer and non-ulcer patients did not differ but was twice as high as in the gastric ulcer patients. The duodenal gastrin-like activity in the duodenal ulcer and the non-ulcer patients did not differ and was about one-third of the antral activity; in the gastric ulcer patients the activity was too low to be estimated. It is concluded that the antral and duodenal gastrin activity is normal in duodenal ulcer patients and below normal in gastric ulcer patients.

Key-words:

• Duodenal ulcer
• duodenum
• gastric ulcer
• gastric mucosa
• gastrin