Effect of Oxyphencyclimine Hydrochloride on Basal Gastric Secretion of Acid and Pepsin in Man

Abstract

A double-blind trial with oxyphencyclimine hydrochloride and placebo was carried out in 13 patients with dyspepsia, of whom 9 had previously had duodenal ulcers. Eleven of the patients remained for evaluation. Ten mg of oxyphencyclimine perorally decreased mean basal volume, acid and pepsin output by about 60 per cent. Acid and pepsin concentration and pepsin/acid ratio were not significantly affected. Oxyphencyclimine had no significantly better effect on the dyspeptic complaints than placebo. The effect of oxyphencyclimine was similar after 1 week and after 2 months of treatment.

Key-words:

• Duodenal ulcer
• hydrochloric acid determination
• parasympaticolytics
• pepsin
• stomach