Absorption of Cyanocobalamin, Coenzyme B₁₂, Methylcobalamin, and Hydroxocobalamin at Different Dose Levels

J. F. Adams Dept. of Medicine, Southern General Hospital, Glasgow, Scotland, Glaxo Limited, Greenford, England, and Scottish Research Reactor Centre, East Kilbride, Scotland

Sheila K. Ross Dept. of Medicine, Southern General Hospital, Glasgow, Scotland, Glaxo Limited, Greenford, England, and Scottish Research Reactor Centre, East Kilbride, Scotland

L. Mervyn Dept. of Medicine, Southern General Hospital, Glasgow, Scotland, Glaxo Limited, Greenford, England, and Scottish Research Reactor Centre, East Kilbride, Scotland

K. Boddy Dept. of Medicine, Southern General Hospital, Glasgow, Scotland, Glaxo Limited, Greenford, England, and Scottish Research Reactor Centre, East Kilbride, Scotland

Priscilla King Dept. of Medicine, Southern General Hospital, Glasgow, Scotland, Glaxo Limited, Greenford, England, and Scottish Research Reactor Centre, East Kilbride, Scotland

Abstract

The whole body retention of radioactive cyanocobalamin, coenzyme B₁₂, methylcobalamin, and hydroxocobalamin was measured by whole body monitoring after oral doses of 1, 5 and 25 μg. At each dose level there were significant differences between the values for whole body retention of the different cobalamins.

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Absorption of Cyanocobalamin, Coenzyme B₁₂, Methylcobalamin, and Hydroxocobalamin at Different Dose Levels

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Absorption of Cyanocobalamin, Coenzyme B₁₂, Methylcobalamin, and Hydroxocobalamin at Different Dose Levels