Influence of Bile Salts on Intestinal Sugar Transport In Vivo

Abstract

The effect of bile salts on the transport of glucose and its non-metabolized analogue, arbutin, was studied in rats in vivo. The more rapid transport of glucose than its analogue found under normal conditions suggests that the metabolic disappearance of glucose by the enterocyte contributes to its removal from the lumen. Sugar transport was unaffected by conjugated bile salt but markedly inhibited by deconjugated bile salt. This inhibitory effect was not modified by the simultaneous addition of conjugated bile salt to the perfusate. The importance of deconjugation of bile salts to intestinal sugar transport in vivo is thus established.

Key-words:

• Bile salt
• glucose
• intestinal transport
• monosaccharide
• rats