Pig-Liver Perfusion

Extracorporeal Pig-Liver Perfusion in a Patient with Acute Hepatic Failure

M. Lempinen The Second and Third Depts. of Surgery, University Central Hospital, Helsinki, and the Second Dept. of Pathology, University of Helsinki, Helsinki, Finland

Y. Collan The Second and Third Depts. of Surgery, University Central Hospital, Helsinki, and the Second Dept. of Pathology, University of Helsinki, Helsinki, Finland

A. Sivula The Second and Third Depts. of Surgery, University Central Hospital, Helsinki, and the Second Dept. of Pathology, University of Helsinki, Helsinki, Finland

E. Merikallio The Second and Third Depts. of Surgery, University Central Hospital, Helsinki, and the Second Dept. of Pathology, University of Helsinki, Helsinki, Finland

K. Salmenkivi The Second and Third Depts. of Surgery, University Central Hospital, Helsinki, and the Second Dept. of Pathology, University of Helsinki, Helsinki, Finland

M. Paloheimo The Second and Third Depts. of Surgery, University Central Hospital, Helsinki, and the Second Dept. of Pathology, University of Helsinki, Helsinki, Finland

M. T. Turunen The Second and Third Depts. of Surgery, University Central Hospital, Helsinki, and the Second Dept. of Pathology, University of Helsinki, Helsinki, Finland

E. J. Jokinen The Second and Third Depts. of Surgery, University Central Hospital, Helsinki, and the Second Dept. of Pathology, University of Helsinki, Helsinki, Finland

J. Ahlqvist The Second and Third Depts. of Surgery, University Central Hospital, Helsinki, and the Second Dept. of Pathology, University of Helsinki, Helsinki, Finland

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Abstract

Three extracorporeal pig-liver perfusions on a patient, for the treatment of an acute hepatic failure, are described. The patient had massive postoperative necrosis of the liver, possibly due to halothane sensitization. There was an improvement in the patient's condition after the perfusions, but she died a few days later of a pulmonary embolism. Comparison between the pre-perfusion biopsy and autopsy specimens showed that liver cell regeneration had occurred. Histological study of the pig livers from the first two perfusions showed an accumulation of granulocytes in the liver sinusoids. The third perfusion had to be stopped after 20 minutes, owing to an acute increase in flow resistance. In this case, the histological study revealed compression of the sinusoids by oedematous liver cells and congestion of the portal areas.

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Pig-Liver Perfusion

Extracorporeal Pig-Liver Perfusion in a Patient with Acute Hepatic Failure

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Pig-Liver Perfusion

Extracorporeal Pig-Liver Perfusion in a Patient with Acute Hepatic Failure

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