Acid Responses of Denervated Fundic (Heidenhain) Pouches to Meals Compared with Those to Histamine and Pentagastrin

A. E. O. Wasunna University Department of Surgery, Western Infirmary, Glasgow, W. 1., and Wellcome Surgical Research Institute, Garscube Estate, Bearsden, Glasgow, Scotland

B. F. Buxton University Department of Surgery, Western Infirmary, Glasgow, W. 1., and Wellcome Surgical Research Institute, Garscube Estate, Bearsden, Glasgow, Scotland

B. S. Bedi University Department of Surgery, Western Infirmary, Glasgow, W. 1., and Wellcome Surgical Research Institute, Garscube Estate, Bearsden, Glasgow, Scotland

I. E. Gillespie University Department of Surgery, Western Infirmary, Glasgow, W. 1., and Wellcome Surgical Research Institute, Garscube Estate, Bearsden, Glasgow, Scotland

Abstract

Gastric acid responses to meals were compared with those to histamine and pentagastrin in 3 dogs with Heidenhain pouches. Large single feeds resulted in acid outputs that were approximately equal to the maximal response to histamine. The maximal acid response to pentagastrin was less than 50% of that to the meal or to the maximal dose of histamine. It is suggested that combinations of endogenously released stimuli (in response to a meal) can produce a potentiated gastric response which exceeds that produced by pentagastrin (exogenous gastrin) alone.

Key-words:

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Acid Responses of Denervated Fundic (Heidenhain) Pouches to Meals Compared with Those to Histamine and Pentagastrin

Information for

Open access

Opportunities

Help and information

Acid Responses of Denervated Fundic (Heidenhain) Pouches to Meals Compared with Those to Histamine and Pentagastrin

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature