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Original Article

Localization of Microbial L-Tyrosine Degradation in the Intestine of Coprophagy-Prevented Rats

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Pages 417-421 | Received 09 Nov 1971, Accepted 15 Feb 1972, Published online: 23 Feb 2010
 

Abstract

The urinary excretion of simple phenols was studied in coprophagy-prevented rats fed a casein-sucrose diet containing added L-tyrosine. After neomycin administered intracaecally the excretion of p-cresol and phenol was only 4% and 20%, respectively, of the amount in sham-operated controls. The excretion of phenols was reduced after prevention of coprophagy, but a similar reduction occurred in rats wearing sham-cups. In rats given 3H-L-tyrosine intragastrically or intracaecally through identical abdominal incisions, the recovery of radioactivity in the simple phenol fraction was 0.5 ± 0.1% and 34 ± 3%, respectively. These findings indicate that the large bowel is capable of absorbing simple phenols and that it is the most important site of microbial L-tyrosine degradation.

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