Gastrin and Acid Studies in the Pouch Dog

Abstract

Serum gastrin and pouch acid secretion were measured in dogs with either innervated (Pavlov) or denervated (Heidenhain) pouches in the basal state and following a meat meal or insulin hypoglycaemia. The gastrin response to meat was consistently greater than to insulin hypoglycaemia and pouch acid output followed the changes in serum gastrin in both groups. These studies confirm that gastrin is the secretagogue responsible for acid secretion from a denervated pouch. They also indicate that intact vagal innervation is essential for the optimal effect of gastrin on acid secretion to be observed.

Key-words:

• Gastric acid
• gastrin
• insulin hypoglycaemia
• meat