A Comparison of Gastric Acid Secretions after Highly Selective Vagotomy without Drainage and Selective Vagotomy with a Pyloroplasty

Abstract

Gastric acid secretion measurements in a controlled double-blind trial, including highly selective vagotomy without drainage and bilateral selective vagotomy with a pyloroplasty for duodenal ulcer, revealed no differences in unstimulated or histamine-stimulated secretion between two paired groups of 30 patients; the insulin-stimulated secretion was higher after highly selective vagotomy, in contrast to other uncontrolled studies. Gastric stasis was absent after both operations. One recurrent and one persistent duodenal ulcer is reported after highly selective vagotomy.

Key-words:

• Duodenal ulcer
• gastric acid secretion
• highly selective vagotomy
• histamine test
• insulin test
• parietal cell vagotomy
• spontaneous acid secretion