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Original article

Response to Duodenal Acidification in Man

IV. Effect on Gastric Emptying

Pages 631-637 | Received 29 May 1972, Accepted 23 Jun 1972, Published online: 23 Feb 2010
 

Abstract

The patterns of gastric emptying of an acid load, or of saline during acid perfusion through the duodenum, have been investigated in healthy subjects and in patients with disease of the upper alimentary tract. The gastric emptying of patients with gastric ulcer was normal. Patients with duodenal ulcer showed either a reversal of the normal pattern with increase in the rate of gastric emptying during duodenal acidification or accentuation of the normal slowing of gastric emptying by acid in the duodenum, like patients with achlorhydria. The latter type of response may prove useful in predicting which patients with duodenal ulcer are likely to develop the clinical syndrome of ‘pyloric stenosis’.

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