9
Views
51
CrossRef citations to date
0
Altmetric
Original article

Precancer and Carcinoma in Chronic Ulcerative Colitis

A Histopathological and Clinical Investigation

, &
Pages 663-669 | Received 02 May 1972, Accepted 20 Jun 1972, Published online: 23 Feb 2010
 

Abstract

Sixty patients with chronic ulcerative colitis and carcinoma have been studied. The morphological features of the tumours and colonic mucosa were examined in 27 cases. The long-term outcome of the total material was estimated. The patient's age at which the carcinoma developed was low and the prognosis mostly unfavourable (5-year survival about 25%). The bad prognosis seems to be an expression of a specific tumour biology at that particular age rather than characteristic features of colitic carcinoma per se. since the histological features of the idiopathic colo-rectal carcinomas in patients at the same age arc very similar to the colitic carcinomas. Precancerous mucosal changes could be demonstrated in all cases except one. The occurrence of precancerous changes in a rectal biopsy seems to justify a prophylactic proctocolectomy, since these patients have a special risk of developing a colonic carcinoma.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.