Radioimmunoassay of Gastrin with Activated Charcoal

Abstract

When activated charcoal was used in the radioimmunoassay of gastrin, a precision of 8.0–12.4 per cent was achieved within assay. Between assays a precision of 10.8 per cent was found. The sensitivity was 1.5 pg/tube and the accuracy 94–104 per cent. The mean values (±S.D.) of gastrin in the serum were 62±32 pg/ml in subjects without gastrointestinal disease, 62±24 pg/ml in patients with duodenal ulcer, 114±78 pg/ml in patients with gastric ulcer, and 630 to 2380 pg/ml in 3 patients with the Zollinger-Ellison syndrome.

Key-words:

• Charcoal
• duodenal ulcer
• gastrin
• Zollinger-Ellison syndrome