Light and Electron Microscopical Studies of Parietal Cells before and one Year after Proximal Gastric Vagotomy in Duodenal Ulcer Patients

Abstract

In 4 duodenal ulcer patients the morphology of parietal cells has been studied before and one year after proximal gastric vagotomy (PGV). The average basal gastric acid secretion of the 4 patients was reduced from 9.2 m.mol/h before to 0.9 m.mol/h one year after PGV (90% reduction). The reduction in acid secretion was not accompanied by changes in the morphology of the parietal cells. Light microscopical studies indicated that the average cell size was about the same before and one year after PGV. Electron microscopical studies showed only negligible changes in the parietal cell ultra-structure.

Key-words:

• Electron microscopy
• gastric mucosa
• gastric secretion
• parietal cell
• stereology
• ulcer, duodenal
• vagotomy, proximal gastric