Heme Catabolism in Liver Cirrhosis with Portal Hypertension after Shunt Surgery

Abstract

Endogenous production of carbon monoxide (VCO), total and direct reacting, serum bilirubin (TSB, DRB) were determined in 26 patients with liver cirrhosis and portal hypertension to evaluate the effect of various shunt operations on total heme catabolism. The material was divided into 3 groups. In group I, 11 patients not operated upon, mean VCO (±S.D.) was 18.4 ±6.0 μmol/mmol total body heme per day (reference value 12.6 ±2.9). In group II, 7 patients operated upon with subcutaneous transposition and a subtotal resection of the spleen, mean VCO (14.4±4.7) was not significantly raised. In group III, 8 patients operated upon with a modified distal splenorenal shunt, the highest mean VCO (26.1 ±9.0) was found. Mean TSB in the three groups was 34.8±29.2, 11.2±3.0, and 46.4±41.0 μmol/l, respectively, and mean DRB 18.2±20.8, 3.7±1.0, and 26.8±34.1 μmol/l, respectively. Estimated from preoperative laboratory values there was no difference in liver function between the three groups.

The conclusion drawn is that heme catabolism, increased by 50 per cent in liver cirrhosis complicated by portal hypertension probably due to a slight decrease in erythrocyte survival, tends to normalize after subcutaneous transposition and subtotal resection of the spleen. After spleno-renal shunting, on the other hand, a further increase in heme catabolism is seen. And so the increase in serum bilirubin often seen after the latter type of surgery is mainly related to a raised bilirubin production and not to a further decrease in liver function.

Key-words:

• Bilirubin
• carbon monoxide
• heme
• heme catabolism
• liver cirrhosis
• portal hypertension