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Original Article

The Role of Local Cholinergic Pathways in the Motor Response to Cholecystokinin and Gastrin in Isolated Guinea-pig Fundus and Antrum

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Pages 751-757 | Received 16 Nov 1976, Accepted 15 May 1977, Published online: 23 Feb 2010
 

Abstract

Both cholecystokinin (CCK-PZ) and gastrin stimulated antral rhythmic activity and raised fundal basal pressure. The antral motor effects were significantly blocked by pretreatment with atropine or tetrodotoxin. The fundal motor responses were almost unaffected. It is concluded that CCK-PZ and gastrin exert their antral motor effects essentially through local cholinergic neural pathways, while the motor responses in the fundus are almost entirely independent of these pathways.

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