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Scandinavian Journal of Gastroenterology Volume 13, 1978 - Issue 2
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Original Article

Methyl-Prostaglandin E2 Analogues for Healing of Gastro-Duodenal Ulcers

J. Rybicka Dept. of Gastroenterology, Inst. Int. Med. Silesian School of Medicine, Katowice, Poland
&
K. Gibiński Dept. of Gastroenterology, Inst. Int. Med. Silesian School of Medicine, Katowice, Poland
Pages 155-159 | Received 21 Aug 1977, Accepted 10 Oct 1977, Published online: 23 Feb 2010
 
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Abstract

117 patients were submitted to the randomized double-blind clinical trial. Methylated analogues of prostaglandin administered orally markedly suppressed gastric acid secretion and—in comparison to placebo—accelerated cicatrization of duodenal ulcers, but not of gastric ulcers. The resistance of some ulcers to healing was not dependent on gastric acid secretion.

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