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Original Article

Anti-fibrinolytic Therapy of Giant Hypertrophic Gastritis (Menetrier's Disease)

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Pages 851-856 | Received 27 Sep 1977, Accepted 25 May 1978, Published online: 23 Feb 2010
 

Abstract

In five cases of giant hypertrophic gastritis (Menetrier's disease) biopsied gastric mucosa was examined for fibrinolytic activity: in all cases there was marked elevation of the activity due mainly to tissue plasminogen activator. The patients were given antifibrinolytic therapy with oral tranexamic acid (trans-4-aminomethyl cyclohexane carboxylic acid: trans-AMCHA), and four of the patients showed marked improvement of their hypoproteinemia as well as their mucosal disorders. One patient, who showed moderate increase of serum protein level but no reduction of the mucosal disorder, finally received gastrectomy. It was concluded that antifibrinolytic therapy seemed to block the vicious circle of membrane disorder', ‘increased tissue fibrinolysis', ‘increased vascular permeability’ and ‘hypoproteinemia’ in Menetrier's disease.

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